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AMG 747

CAS No. 1000690-85-6

AMG 747( AMG747 | AMG-747 )

Catalog No. M10008 CAS No. 1000690-85-6

A nanomolar potent, selective, and orally bioavailable glycine transporter type-1 (GlyT1) inhibitor for the treatment of negative symptoms associated with schizophrenia.

Purity : >98% (HPLC)

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Biological Information

  • Product Name
    AMG 747
  • Note
    Research use only, not for human use.
  • Brief Description
    A nanomolar potent, selective, and orally bioavailable glycine transporter type-1 (GlyT1) inhibitor for the treatment of negative symptoms associated with schizophrenia.
  • Description
    A nanomolar potent, selective, and orally bioavailable glycine transporter type-1 (GlyT1) inhibitor for the treatment of negative symptoms associated with schizophrenia; dose-dependently increases cerebrospinal fluid (CSF) glycine concentration in rats and humans.Schizophrenia Phase 2 Discontinued
  • In Vitro
    ——
  • In Vivo
    Tilapertin is a nanomolar potent, orally bioavailable and selective GlyT1 inhibitor. Oral administration of Tilapertin dose-dependently increases cerebrospinal fluid (CSF) glycine concentration in rats.
  • Synonyms
    AMG747 | AMG-747
  • Pathway
    Membrane Transporter/Ion Channel
  • Target
    GlyT
  • Recptor
    GlyT
  • Research Area
    Neurological Disease
  • Indication
    Schizophrenia

Chemical Information

  • CAS Number
    1000690-85-6
  • Formula Weight
    378.395
  • Molecular Formula
    C20H21F3N2O2
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    O=C(O)CN1CCN([C@H](C2=CC=CC=C2)C3=CC=CC(C(F)(F)F)=C3)CC1
  • Chemical Name
    1-Piperazineacetic acid, 4-[(R)-phenyl[3-(trifluoromethyl)phenyl]methyl]-

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Dunayevich E, et al. Schizophr Res. 2017 Apr;182:90-97.
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